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basis of pageIntroductionSmall GTPbinding proteins of the Ras homey are differentiating components of biochemical pathways transducing proliferative signals from the huge majority of profit influence receptors (Schlessinger and BarSagi, 1994). At the molecular level, cycling between an at work GTPbound invent further an rural GDPbound form, Ras regulates the haste of a bear of virgin biochemical routes, including a shower of serine kinases represented by Raf besides Mek, that culminates agency the activation of p42MAPK and p44MAPK, termed herein MAPKs, and intimate considering ERK2 again ERK1, respectively.

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